Transplants Networks

A connected platform that helps transplant networks streamline allocation, strengthen oversight, and improve access to transplants.

Transparent, Accountable Allocation at National Scale

A jurisdictional transplant network is not a bigger transplant center — it's a different problem entirely. Thousands of concurrent match runs. Dozens of policies that change as clinical evidence evolves. Equity requirements that span geographies and demographics. Offers that must move in minutes, not hours. Afflo is the only allocation platform built specifically for this layer of transplantation: the network itself.

Afflo’s model is built on centralized intelligence through its Afflo Central Hub, which connects transplant centers (TXCs) into a unified operational network. Rather than each center managing coordination independently, the Central Hub aggregates real-time data, standardizes workflows, and orchestrates decision-making across all sites.

Afflo gives transplant networks the infrastructure to govern policy, drive equity, and answer to every stakeholder with confidence.

Align stakeholders across the transplant network

Allocation Infrastructure Built for Scale

Afflo is built for the network layer of transplantation. It unifies matching logic, policy configuration, immunologic precision, and offer coordination in a single operational system that supports high-volume matching and live offer execution while preserving governance, equity, and speed.

Fewer Non-Productive Offers, Faster Offer Completion

Afflo reduces non-productive offers by improving match quality before an offer is sent. The allocation engine applies clinical, operational, and policy-specific constraints to produce offers with higher relevance and complete context from the outset.

Networks using Afflo can:

Reduce offer churn and unnecessary declines

Run parallel, automated offer cycles across channels

Deliver complete context earlier to decision-makers

Keep organs moving when primary offers are declined

The result: faster decisions and better utilization across the network.

Allocation policies evolve as clinical evidence grows. Afflo's Policy Management Workbench lets jurisdictional teams configure, update, and govern matching logic directly, without heavy IT involvement. Afflo supports:

Policy Management Designed for Continuous Evolution

Continuous Distribution Frameworks

Apply allocation rules across the waitlist without relying on rigid categories

Category-based and hybrid ranking models

Support both traditional and flexible ranking approaches to match policy and clinical priorities

Center-specific and geography-specific rollout strategies

Tailor policy updates by center or region, implementing changes while minimizing disruption

Incremental adoption by organ type or phase

Introduce changes step-by-step for specific organs or rollout phases

Networks move faster while maintaining full oversight and accountability.

High-Resolution Matching That Expands Access

Afflo's virtual crossmatch engine operates at high immunologic resolution, including:

Allele-specific typing
Alpha-beta HLA interpretation
Epitope and eplet-level policy support
Highly sensitized patient optimization

This precision improves match confidence, reduces unexpected positive crossmatches, and expands access for harder-to-place patients.

For distance placements, high-resolution VXM is especially critical, reducing discards and negative outcomes where time and travel amplify risk.

Simulate Policy Changes Before They Go Live

Afflo lets networks test policy changes before they go live, not after.

Policy Forge

Manage exclusion, ranking, and decline logic without operational disruption.

Policy Time Machine

Simulate any policy change against historical allocation data to confirm expected outcomes and surface unintended consequences before going live.

The result: faster iteration, lower implementation risk, and stronger governance.

Audit-Ready Documentation and Governance

Afflo captures allocation logic and policy configuration in a structured, documentation-ready format. Rule tracking and data dictionaries support:

Audit readiness and regulatory compliance
Transparent governance across jurisdictions
Knowledge transfer and operational continuity
Continuous improvement without losing accountability

Network Effects That Strengthen Every Center

Afflo gives networks something they have historically lacked: shared operational learning at scale. Consistent workflows, shared allocation infrastructure, and real-time visibility help networks operationalize best practices across every center. Networks gain: