National-Scale Allocation Infrastructure for Transplant Networks

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Afflo is the allocation and policy platform built specifically for national and jurisdictional transplant networks, enabling faster matches, more precise offers, and system-wide continuous improvement.

Align stakeholders across the transplant network

Allocation Infrastructure Built for Scale

National transplant networks rely on allocation infrastructure built for real-time scale and policy complexity. Afflo supports high-volume matching and live offer execution while preserving governance, equity, and speed.

Afflo was designed for this layer of transplantation: the network itself. Our platform unifies matching logic, policy configuration, immunologic precision, and offer coordination into a single operational system that grows with demand.

Fewer Non-Productive Offers, Faster Offer Completion

Afflo reduces non-productive offers by improving match quality upstream, before an offer is ever sent. Our allocation engine applies a broader and more precise set of clinical, operational, and policy-specific constraints, producing offers with higher relevance and stronger context from the outset.

Networks using Afflo can:

Reduce offer churn and unnecessary declines

Run parallel, automated offer cycles across channels

Deliver complete context earlier to decision-makers

Keep organs moving when primary offers are declined

The result is faster decision timelines and better utilization across the network.

Transplant allocation policies change over time as clinical evidence grows and system needs evolve. Afflo makes it easier for networks to update and govern policy without slowing down operations.

Afflo’s Policy Management Workbench enables jurisdictional policy teams to configure, maintain, and govern matching logic directly, without heavy IT involvement.

Afflo supports:

Policy Management Designed for Continuous Evolution

Continuous Distribution Frameworks

Apply allocation rules across the waitlist seamlessly, without relying on rigid categories

Category-based and hybrid ranking models

Support traditional and flexible ranking approaches to match policy and clinical priorities

Center-specific and geography-specific rollout strategies

Tailor policy updates for individual centers, allowing networks to implement changes while minimizing disruption and operational risk

Incremental adoption by organ type or phase

Introduce changes step-by-step for specific organs or rollout phases, keeping operations smooth

This allows networks to move faster while maintaining full oversight and accoutnability

High-Resolution Matching That Expands Access

Afflo’s Matching and Offer Engine implements advanced virtual crossmatch algorithms that operate at high immunologic resolution, including:

  1. Allele-specific typing

  2. Alpha-beta HLA interpretation

  3. Epitope and eplet-level policy support

  4. Highly sensitized patient optimization

This level of precision improves match confidence, reduces unexpected positive crossmatches, and can extend access for patients who are traditionally harder to place.

For distance placements, where time and travel amplify risk, high-resolution VXM becomes even more critical to reduce discards and negative outcomes.

Simulate Policy Changes Before They Go Live

Afflo gives networks the ability to test policy safely, not after implementation, but before deployment.

Policy Forge

Allows policy experts to manage sophisticated exclusion, ranking, and decline logic without operational disruption.

Policy Time Machine

What began as a passion project has evolved into something more. We’re proud of where we’ve been and even more excited for what’s ahead.

Policy change simulations support faster policy iteration, lower implementation risk, and stronger governance and fewer unintended consequences.

High-Resolution Matching That Expands Access

Afflo captures allocation logic and policy configuration in a documentation-ready structure.

Automated artifacts, including rule tracking and data dictionaries, support:

  • Audit readiness and regulatory compliance

  • Transparent governance across jurisdictions

  • Knowledge transfer and operational continuity

  • Continuous improvement without losing accountability

Network Effects That Strengthen Every Center

Afflo enables something transplant networks have historically lacked: shared operational learning at scale. By connecting centers through consistent workflows, shared allocation infrastructure, and real-time system visibility, Afflo helps networks operationalize best practices across peer programs.

Networks gain:

  • Streamlined coordination across all stakeholders

    Streamlined coordination across all stakeholders

  • Faster alignment across jurisdictions and centers

    Faster alignment across jurisdictions and centers

  • Shared learnings from live allocation performance

    Shared learnings from live allocation performance

  • System-wide improvement that benefits every participant

    System-wide improvement that benefits every participant

  • When allocation improves for one center, the entire network becomes stronger.

    When allocation improves for one center, the entire network becomes stronger.

Ready to Strengthen Allocation Across the Network?

Afflo unifies real-time matching, policy governance, high-resolution immunologic precision, and offer execution for transplant networks. Connect with our team to learn how shared infrastructure can improve speed, equity, and utilization across your jurisdiction.

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